Project Description
My research focuses on monitoring, design and control of batch and continuous pharmaceutical crystallization using process analytical technology (PAT) (e.g. UV/vis, FBRM, PVM, online UPLC, Raman), feedback control and population balance modelling to achieve desired crystal size, shape, yield and purity. Three topics are of particular interests: (1) combined cooling/antisolvent crystallization (2) wet-milling integrated crystallization operation (3) additive/impurity effect on crystallization process. The studies are carried out using both experimental and modeling techniques.
Publications and Presentations
Journal
- Yang, Y.; Song, L.; Zhang, Y.; Nagy, Z. K. "Application of Wet Milling Based Automated Direct Nucleation Control in Continuous Cooling Crystallization Processes", Ind. Eng. Chem. Res. 2016. DOI: 10.1021/acs.iecr.5b04956
- Yang, Y.; Song, L.; Gao, T.; Nagy, Z. K. “Integrated Upstream and Downstream Application of Wet Milling with Continuous Mixed Suspension Mixed Product Removal Crystallization”, Cryst. Growth Des. 2015, 15, 5879–5885.
- Yang, Y.; Song, L.; Nagy, Z. K. “Automated Direct Nucleation Control in Continuous Mixed Suspension Mixed Product Removal Cooling Crystallization”, Cryst. Growth Des. 2015, 15, 5839–5848.
- Yang, Y.; Nagy, Z. K. "Advanced Control Approaches for Combined Cooling/Antisolvent Crystallization in Continuous Mixed Suspension Mixed Product Removal Cascade Crystallizers", Chem. Eng. Sci. 2015, 127, 362–373.
- Yang, Y.; Nagy, Z. K. "Combined Cooling and Antisolvent Crystallization in Continuous Mixed Suspension, Mixed Product Removal Cascade Crystallizers: Steady-state and Startup Optimization", Ind. Eng. Chem. Res. 2015, 54, 5673–5682.
- Yang, Y.; Nagy, Z. K. "Model-based Systematic Design and Analysis Approach for Unseeded Combined Cooling and Antisolvent Crystallization (CCAC) Systems", Cryst. Growth Des. 2014, 14, 687–698.
- Yang, Y.; Nagy, Z. K. "Application of Nonlinear Model Predictive Control in Continuous Crystallization Systems", American Control Conference 2015, 4282–4287.
- Ding, Y.; Yang, Y.; Yang, L.; Yan, Y.; Huang, J. "A Case of Adaptive Self-Assembly", ACS nano 2012, 6, 1004–1010.
- Wang, J.; Yang, Y.; Yan, Y.; Huang, J. “Fluorescent Microcapsules Based on Coordination Supramolecular Polymers of Rare Earth Metal Ions”, Acta Physico-Chimica Sinica 2012, 28, 2291–2297
- Yang, L.; Ding, Y.; Yang, Y.; Yan, Y.; Huang, J. "Fluorescence Enhancement by Microphase Separation-Induced Chain Extension of Eu3+ Coordination Polymers: Phenomenon and Analysis", Soft Matter 2011, 7, 2720–2724.
Experience
- Science intern, AbbVie Inc., North Chicago, IL (May 2014 – Aug. 2014)
Awards
- Eastman Travel Award, Purdue University (2014)
- GAW Scholarship, Purdue University (2012)
- Certified LABVIEW Associate Developer (CLAD), National Instruments (May '15 – May '17)
- Golden Key International Honor Society Member (Aug. 2015 – Present)
Education
|
